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The role of NK family receptor interactions with HLA-B27 in Ankylosing Spondylitis pathogenesis

Abstract:

Possession of the Major Histocompatibility Complex (MHC) allele, HLA-B27 (B27), strongly predisposes to the development of spondyloarthritis. Furthermore, B27 exists as polymorphic variants, with some subtypes (such as B*2705) being more strongly associated with disease than others (B*2709). The immunological function of MHC molecules is to present peptides in a heterotrimeric complex with beta-2-microglobulin (β2m); however, B27 has also been observed to form non-classical (β₂m –free) hom...

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Institution:
University of Oxford
Research group:
Human Immunology Unit
Oxford college:
St Anne's College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Joanna Giles
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:660f1445-d773-4a4e-91d3-fdadf957795c
Local pid:
ora:5665
Language:
English
Keywords:
Subjects:

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