Lentiviral delivery of CRISPR Cas9 prime editing system for cystic fibrosis

Thesis

The field of gene editing is rapidly developing, particularly with advancements in gene editor technologies. Prime editing has been a significant breakthrough in gene editing, allowing precise, targeted correction of all types of DNA mutation, including insertion, deletion, and base substitutions, without inducing double strand breaks in the genome. Along with other gene editing tools based on the CRISPR-Cas9 technology, prime editing is being extensively researched for its potential to co...

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Authors: Satyapertiwi, D

• DOI: 10.5287/ora-br2dmyv6z
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: CRISPR; lentiviral vector; cystic fibrosis; prime editing
• Subjects: Lentiviral vector; Gene editing