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Thesis

Lentiviral delivery of CRISPR Cas9 prime editing system for cystic fibrosis

Abstract:

The field of gene editing is rapidly developing, particularly with advancements in gene editor technologies. Prime editing has been a significant breakthrough in gene editing, allowing precise, targeted correction of all types of DNA mutation, including insertion, deletion, and base substitutions, without inducing double strand breaks in the genome. Along with other gene editing tools based on the CRISPR-Cas9 technology, prime editing is being extensively researched for its potential to co...

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Institution:
University of Oxford
Division:
MSD
Department:
Radcliffe Department of Medicine
Research group:
Gill and Hyde Group: Gene Medicine Group
Oxford college:
Exeter College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Radcliffe Department of Medicine
Research group:
Gill and Hyde Group: Gene Medicine Group
Role:
Supervisor
ORCID:
0000-0002-5264-054X
Institution:
University of Oxford
Division:
MSD
Department:
Radcliffe Department of Medicine
Research group:
Gill and Hyde Group: Gene Medicine Group
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Radcliffe Department of Medicine
Research group:
Gill and Hyde Group: Gene Medicine Group
Role:
Supervisor
ORCID:
0000-0002-3196-6612


DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford


Language:
English
Keywords:
Subjects:
Deposit date:
2025-03-03
ARK identifier:

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