Thesis
Structural and kinetic studies on beta-lactamase mechanism and inhibition
- Abstract:
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Beta-lactamases constitute one of the most prevalent identified mechanisms of bacterial resistance to the beta-lactam antibiotics. These enzymes are broadly divided into two mechanistic subclasses, the serine-beta-lactamases and the metallo-beta-lactamases. The metallo-beta-lactamases constitute an important subclass of beta-lactamases on account of their ability to hydrolyse almost all classes of beta-lactam, in particular the carbapenems, which are considered to be beta-lactams of last r...
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Actions
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
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uuid:65cf9890-54ba-4399-8a56-bbd62d604ca6
- Deposit date:
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2018-06-28
Terms of use
- Copyright holder:
- Cahill, S
- Copyright date:
- 2017
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