Bladder microstructural and biomechanical modelling: in vivo, in vitro and in silico

Thesis

Lower urinary tract disorders are significant prognostic indicators of institutionalisation and lower quality of life in the elderly and their incidence increases with age. Urodynamics, the gold standard in diagnosis, replicates symptoms to assess functionality through controlled filling and voiding of the bladder but its interpretation is subjective and may be inconclusive; often requiring further testing or leading to inappropriate treatment. Normal filling and voiding biomechanics ...

Expand abstract

Authors: Hornsby, J

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Keywords: microstructural model; collagen model; multiphoton microscopy; bladder; lower urinary tract
• Subjects: Mechanical testing; Microstructural modelling; multiphoton microscopy; Lower urinary tract