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Thesis

Genetic risk and resilience for Alzheimer’s disease: The effect of the three APOE alleles on brain function across life

Abstract:

The human apolipoprotein E (APOE) gene has three alleles (ε2, ε3 and ε4). Relative to the most common ε3 allele, ε4 is associated with a higher risk of developing sporadic late-onset Alzheimer’s disease (AD) whereas ε2 is believed to confer a protection to AD. Because of ε4's close association with cognitive decline, the majority of APOE-research has focused on this allele, with ε2 receiving little attention. This DPhil thesis used advanced multi-modal magnetic resonance imaging techniques...

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Division:
MSD
Role:
Author

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Supervisor
Role:
Supervisor
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Funding agency for:
Suri, S
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:6312d276-1c50-4198-8a7f-d48528191506
Deposit date:
2017-02-02

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