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Design and synthesis of inositol phosphate-based probes

Abstract:

Inositol phosphates play a fundamental role in many intracellular processes. Of particular importance is the role of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] in the protein kinase B (PKB/Akt) signalling pathway. PtdIns(3,4,5)P3 recruits PKB to the cell membrane through binding interactions with its pleckstrin homology (PH) domain. In several human cancers, this signalling pathway is upregulated, resulting in increased cell growth and proliferation. In order to investigate...

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Institution:
University of Oxford
Research group:
Stuart Conway
Oxford college:
St Hugh's College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:62687744-69b5-420c-9afa-b549bbe39ec4
Local pid:
ora:6883

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