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Thesis

Targeting polymer coated adenovirus to tumour-associated vasculature

Abstract:

Tumour-associated vasculature provides an accessible target for systemic gene therapy using targeted adenoviruses. The aim of this thesis is to develop strategies for targeting adenovirus infection to tumour-associated endothelium.

Adenovirus expressing luciferase (Adluc) was coated with an amino-reactive polymer based on poly [N-(2-hydroxypropyl) methacrylamide] [pHPMA] to ablate normal infection pathways¬. This was a pre-requisite to redirecting virus tropism to infect endothelia...

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Institution:
University of Oxford
Oxford college:
Brasenose College
Department:
Medical Sciences Division - Clinical Pharmacology
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:602123e8-814c-4b63-a482-ab8adcfa6594
Local pid:
ora:5644

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