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Thesis

Novel di-branched monosaccharides and imino sugars

Abstract:

Branched chain sugars display a varied and valuable range of biological activities. This thesis concerns the synthesis of 3,5-di-C-methyl-D-glucose, a potential inhibitor of glycogen phosphorylase (GP), and therefore a proposed therapeutic agent for type 2 diabetes. Chapter 1 looks at the occurrence of branched sugars in the natural world and current therapies for type 2 diabetes. Inhibition of GP is explored, and the molecular modelling studies which led to the design of the project targe...

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Institution:
University of Oxford
Research group:
Professor George Fleet
Oxford college:
St John's College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory

Contributors

Role:
Supervisor
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:5e9ef70b-9213-4c0c-b500-61200a049c1b
Local pid:
ora:6146

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