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Thesis

The genetics of autoimmune and proteinuric disease

Abstract:

The genetics of complex common diseases are not fully understood, but rare variants with large phenotypic effects contribute to heritability. The objective of this thesis is to identify rare variants of relevance to autoimmune and renal disease, by developing ways of analysing whole genome sequencing (WGS) data and exploring the variants identified. Forward genetic experimental approaches are used, both in mutagenised mice, and in humans with extreme trait forms of the steroid resistant ne...

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Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:5e93c208-c9df-44eb-87db-9c20622ca207
Deposit date:
2016-02-11

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