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Thesis

KDM2A and KDM2B mediate widespread transcription repression in mouse embryonic stem cells

Abstract:

DNA methylation is widespread in vertebrate genomes, occurring on cytosine residues in the context of CpG dinucleotides. An important exception to this pervasive methylation are CpG islands (CGIs), short regions of CpG rich, non-methylated DNA that are associated with the majority of transcription start sites. CGIs are bound by proteins containing a zinc finger-CXXC (ZF-CXXC) domain, which specifically recognises nonmethylated CpG dinucleotides. These proteins are found in a variety of chr...

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Anne Turberfield More by this author

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Role:
Supervisor
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Funding agency for:
Anne Turberfield
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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