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Thesis

Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases

Abstract:

The hypoxia-inducible factor (HIF) is a key regulator of transcriptional responses to hypoxia in animals. As part of the cellular response to decreased oxygen concentrations, the transcriptional activity of a heterodimeric complex consisting of HIFα and HIFβ activates the expression of hundreds of target genes, including those involved in cellular growth, apoptosis, energy metabolism and angiogenesis. HIFα prolyl hydroxylation, as catalysed by the HIF prolyl hydroxylases (PHDs), lead...

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Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Department:
University of Oxford
Role:
Author

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Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:5c8a24bd-3acc-4271-a24b-8bd601d7a807
Deposit date:
2015-09-29

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