Thesis
The role of nitric oxide synthase (nos) and the cofactor tetrahydrobiopterin (bh4) in diabetic cardiomyopathy
- Abstract:
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The work presented within this thesis investigates the mechanisms which underlie the cardiovascular phenotype observed in a mouse model of type 1 diabetic cardiomyopathy. It demonstrates the protective effects of augmenting the NOS cofactor, BH4, to said cardiomyopathy, and explores the different pathways potentially involved in conferring protection.
Chapter 1 summarises the current understanding of how hyperglycaemia triggers dysfunction in the vascular endothelium via the ...
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- Files:
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(Preview, Dissemination version, pdf, 4.1MB, Terms of use)
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Authors
Contributors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
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uuid:5aae83b5-4c50-47fb-8528-1c39c83fcc1a
- Deposit date:
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2016-04-13
- ARK identifier:
Terms of use
- Copyright holder:
- Drew Duglan
- Copyright date:
- 2016
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