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Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

Abstract:

Background

Activation of the group 2 innate lymphoid cell (ILC2) population leads to production of the classical type 2 cytokines, thus promoting type 2 immunity. Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), a receptor for prostaglandin D2 (PGD2), is expressed in human ILC2. However, the function of CRTH2 in these cells is unclear.

Objectives

We sought to determine the role of PGD2 and CRTH2 in human ILC2 and compare it with that of ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.jaci.2013.10.056

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Funding agency for:
Klenerman, P
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Allergy and Clinical Immunology Journal website
Volume:
133
Issue:
4
Pages:
1184-1194.e7
Publication date:
2013-12-05
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
URN:
uuid:5882c732-0862-474b-845c-b0f41bf292ba
Source identifiers:
462662
Local pid:
pubs:462662

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