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Thesis

Antihypertensive drug class effects on inter-individual blood pressure variability and the associated risk of stroke

Abstract:

Visit-to-visit variability in systolic blood pressure (SBP) predicts the subsequent risk of stroke, independent of mean SBP. It was reduced by amlodipine and increased by atenolol in the ASCOT-BPLA and MRC randomized controlled trials (RCTs), explaining the difference in risk of stroke between treatment groups that was not explained by mean SBP. Therefore, I performed a series of systematic reviews to examine the effects of all antihypertensive drugs in RCTs and how these effects relate t...

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Institution:
University of Oxford
Research group:
Stroke Prevention Research Unit
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:57346bd2-220e-49a0-bfe6-3e2e522795da
Local pid:
ora:6465

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