Thesis
The chromosomal passenger complex: regulation of chromosome segregation in kinetoplastids
- Abstract:
-
An intricate network of kinases and phosphatases safeguards the fidelity and timeliness of chromosome segregation in eukaryotes. As the catalytic subunit of the chromosomal passenger complex (CPC), the Aurora B kinase plays a pivotal role within this network by destabilizing improper kinetochore-microtubule attachments and relaying the attachment status to the spindle assembly checkpoint. Intriguingly, Aurora B is conserved even in kinetoplastids, an evolutionarily divergent group of eukar...
Expand abstract
Actions
Access Document
- Files:
-
-
(Preview, Dissemination version, pdf, 54.0MB, Terms of use)
-
Authors
Contributors
+ Akiyoshi, B
- Institution:
- University of Oxford
- Role:
- Supervisor
- ORCID:
- 0000-0001-6010-394X
+ Schermelleh, L
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Biochemistry
- Role:
- Supervisor
- ORCID:
- 0000-0002-1612-9699
+ University of Oxford, Department of Biochemistry
More from this funder
- Programme:
- Department of Biochemistry Graduate Studies Scholarship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2024-07-27
- ARK identifier:
Terms of use
- Copyright holder:
- Daniel Ballmer
- Copyright date:
- 2024
If you are the owner of this record, you can report an update to it here: Report update to this record