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Thesis

The role of dendritic cells in determining the breadth and epitope specificity of the initial CD8+ T cell response during acute HIV-1 infection

Abstract:

During acute HIV-1 infection (AHI), CD8+ T cell responses are initially induced to only 1-3 viral epitopes in many patients, and Nef-derived epitopes are very commonly targeted. The earliest CD8+ T cell responses decrease in magnitude as viraemia begins to decline, and are followed by delayed expansion of subsequent waves of responses of broader epitope-specificity. In this thesis, the hypotheses that prevalent presentation of Nef-derived epitopes by dendritic cel...

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Division:
MSD
Department:
NDM
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:568e3b95-15c1-4f5b-b26e-bd3ab7e54ed2
Deposit date:
2017-02-02

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