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Thesis

The roles of Hsp70 proteins in antigen processing and presentation

Abstract:

The ability of members of the hsp70 family to bind to peptides in vivo and in vitro suggests that they may be involved in the processing of antigens for binding to Major Histocompatibility (MHC) class I and/or class n molecules. The aims of this thesis have been to provide evidence for the involvement of hsp70s in antigen processing and to characterise the binding of peptides by hspTOs by structural and functional studies.

Firstly, the peptide-binding domains of t...

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Institution:
University of Oxford
Department:
Dept. of Biochemistry
Publication date:
1997
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
602830411
URN:
uuid:567dff45-08ce-43b4-b011-d08afea42f76
Local pid:
td:602830411

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