Thesis icon

Thesis

MiR-215 regulates differentiation in colorectal cancer stem cells

Abstract:

Since the initial description of cancer stem cells (CSCs) as a self-renewing subpopulation of malignant cells with tumor-initiating capacity, a growing body of evidence has supported the existence of CSCs in virtually every tumor type. Our previous work in colorectal cancer has identified the transcription factor CDX1 as a key regulator of colorectal CSC differentiation. CDX1 expression is frequently lost in colorectal cancer, resulting in more aggressive, poorly differentiated tumors with...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Research group:
Cancer and Immunogenetics Laboratory
Oxford college:
New College
Department:
Medical Sciences Division - Medical Oncology

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:5462857b-4cee-44a8-a299-63b798a67f3f
Local pid:
ora:9141

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP