Using human induced pluripotent stem cells to reveal astrocyte-neuron interactions in health and disease

Thesis

Interactions between neurons and astrocytes underpin normal brain function. Astrocytes fulfil a variety of essential roles, including regulating synapse formation and maintenance, clearing neurotransmitters, and providing homeostatic regulation of the extracellular ionic environment. Evidence for a more active participation is also emerging, in which astrocytes respond to neuronal signals by influencing synaptic strength through gliotransmission. Most of our knowledge regarding neuron-astr...

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Authors: Hedegaard, A

• DOI: 10.5287/ora-brzqonb5z
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English