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Controlling protein orientation in vacuum using electric fields

Abstract:

Single-particle imaging using X-ray free-electron lasers is an emerging technique that could provide high-resolution structures of macromolecules in the gas phase. One of the largest difficulties in realizing this goal is the unknown orientation of the individual sample molecules at the time of exposure. Preorientation of the molecules has been identified as a possible solution to this problem. Using molecular dynamics simulations, we identify a range of electric field strengths where protein...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.jpclett.7b02005

Authors


Marklund, EG More by this author
Ekeberg, T More by this author
More by this author
Department:
University College
Caleman, C More by this author
Publisher:
American Chemical Society Publisher's website
Journal:
Journal of Physical Chemistry Letters Journal website
Volume:
8
Issue:
18
Pages:
4540–4544
Publication date:
2017-09-01
DOI:
ISSN:
1948-7185
Pubs id:
pubs:729003
URN:
uri:50818280-bd9f-4c99-aa94-ecd6e741c23e
UUID:
uuid:50818280-bd9f-4c99-aa94-ecd6e741c23e
Local pid:
pubs:729003
Language:
English

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