Thesis
In vitro experiments towards a mathematical model of solid tumour treatment by thermosensitive liposomes
- Abstract:
-
Thermosensitive Liposomes (TSLs) are at a crossroads as a delivery platform. Recent attempts at clinical translation have had mixed outcomes. The HEAT and OPTIMA trials, using TSL doxorubicin and radiofrequency ablation (RFA) as a heating modality did not demonstrate improved outcomes compared to RFA alone. In contrast, the TARDOX trial demonstrated for the first time that the delivery of TSL doxorubicin with localised ultrasound-mediated mild hyperthermia of a deep-seated tumour was safe ...
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Authors
Contributors
+ Coussios, CC
- Role:
- Supervisor
- ORCID:
- 0000-0001-8792-7818
+ Payne, S
- Role:
- Supervisor
+ Carlisle, R
- Role:
- Supervisor
- ORCID:
- 0000-0003-4508-4802
+ Stride, E
- Role:
- Examiner
- ORCID:
- 0000-0003-3371-5929
+ ten Hagen, T
- Role:
- Examiner
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000266
- Grant:
- 2279640
- Programme:
- EPSRC DTA
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2023-11-10
Terms of use
- Copyright holder:
- Michael D. Newsome
- Copyright date:
- 2023
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