The new pathology: dissecting cellular responses in lupus nephritis

Thesis

SLE is a prototypic chronic autoimmune disease characterised by the production of wide spectrum of autoantibodies to ubiquitous antigens such as anti-dsDNA, targeting multiple organs. Lupus Nephritis (LN) is serious complication of SLE impacting ~50% of people with SLE and characterised by renal immune-complex (IC) deposition. Current methods of classifying LN are reliant on histological and clinical evidence, and do not reliably predict disease progression, while understanding of the cell...

Expand abstract

Authors: Bhandari, A

• DOI: 10.5287/ora-r8norzgpx
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: immune complex deposition; snrna-seq; SLE; lupus nephritis; autoimmunity; renal disease
• Subjects: Immunology; Lupus nephritis; Systemic lupus erythematosus; Autoimmunity