Modulation of ageing characteristics with an anti-ageing compound

Thesis

Investigating the cellular processes anti-ageing compounds interact with can identify genes and pathways involved in ageing. The macrolide lactone FK506 was identified in a phenotypic screen as extending lifespan in yeast and C. elegans through an unknown mechanism. FK506 also ameliorates neurodegeneration and age-related weight gain in rodents. Here, the mechanism of action of FK506 has been investigated in two experimental systems: C. elegans and 3T3-L1 mouse adipocytes...

Expand abstract

Authors: Hall, N

• DOI: 10.5287/ora-5jokdgvak
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: C. elegans; Ageing; Adipocytes
• Subjects: Ageing