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Thesis

Evaluating the biocatalytic potential of a small molecule 2-oxoglutarate dependent halogenase

Abstract:

The late-stage oxidative functionalisation of C-H bonds can be used to circumvent synthetic route re-design and to generate molecules not easily accessible via conventional methods. Such reactions can be problematic due to a lack of site-selectivity and the poor intrinsic reactivity of the C-H bond. Enzymes may provide a solution to both these issues, and enhancements in activity, selectivity, temperature stability and organic solvent tolerance over the wild-type enzyme are achievable by p...

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Department:
Organic Chemistry

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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