Thesis
Blood transcriptomic profiles associated with fatal melioidosis and type 2 diabetes induced susceptibility to intracellular pathogens
- Abstract:
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Background: Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei, and is a leading cause of death from community-acquired infections in Northeast Thailand with a case fatality rate of up to 50%. Most melioidosis patients have one or more comorbidities, and more than half of patients have diabetes which confers a 12-fold increased susceptibility to melioidosis. A similar, but less marked, relationship is seen in tuberculosis (TB) patients, with a 3-fold incr...
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- Files:
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(Preview, Dissemination version, pdf, 27.8MB, Terms of use)
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Authors
Contributors
+ Klenerman, P
- Role:
- Supervisor
- ORCID:
- 0000-0003-4307-9161
+ Kronsteiner-Dobramysl, B
- Role:
- Supervisor
- ORCID:
- 0000-0003-0867-2867
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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1594859
- Local pid:
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pubs:1594859
- Deposit date:
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2023-04-06
- ARK identifier:
Terms of use
- Copyright holder:
- Patpong Rongkard
- Copyright date:
- 2022
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