Blood transcriptomic profiles associated with fatal melioidosis and type 2 diabetes induced susceptibility to intracellular pathogens

Thesis

Background: Melioidosis is caused by the Gram-negative bacterium Burkholderia pseudomallei, and is a leading cause of death from community-acquired infections in Northeast Thailand with a case fatality rate of up to 50%. Most melioidosis patients have one or more comorbidities, and more than half of patients have diabetes which confers a 12-fold increased susceptibility to melioidosis. A similar, but less marked, relationship is seen in tuberculosis (TB) patients, with a 3-fold incr...

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Authors: Rongkard, P

• DOI: 10.5287/ora-jnk8jqm85
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: intracellular infection; diabetes; case fatality; blood transcriptome; melioidosis; sepsis; tuberculosis; bulk RNA-seq; mortality
• Subjects: Septicemia; Intracellular pathogens; Immunology; Bioinformatics; Tropical medicine