Thesis
Targeted release from lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours
- Abstract:
-
The TARDOX study is a Phase I first-in-man proof-of-concept study which aims to demonstrate the safety and feasibility of targeted delivery of a thermo-sensitive liposome in combination with mild hyperthermia induced using an extracorporeal Focused Ultrasound (FUS) device. ThermoDox® is a specially formulated long-circulating and thermosensitive liposome, activated by conditions of mild hyperthermia, to release its cytotoxic doxorubicin content. FUS offers non-invasive and non-ionising app...
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Authors
Contributors
+ Coussios, C
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Engineering Science
- Sub department:
- Institute of Biomedical Engineering
- Role:
- Supervisor
+ Gleeson, F
- Department:
- Department of Radiology, Oxford University Hospitals NHS Foundation Trust
- Role:
- Supervisor
+ Carlisle, R
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Engineering Science
- Sub department:
- Institute of Biomedical Engineering
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:4817361a-e7f8-4773-ac81-8445ace05301
- Deposit date:
-
2017-06-29
Terms of use
- Copyright holder:
- Lyon, P; Celsion Corporation, USA. P C Lyon
- Copyright date:
- 2016
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