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Thesis

Targeted release from lyso-thermosensitive liposomal doxorubicin (ThermoDox®) using focused ultrasound in patients with liver tumours

Abstract:

The TARDOX study is a Phase I first-in-man proof-of-concept study which aims to demonstrate the safety and feasibility of targeted delivery of a thermo-sensitive liposome in combination with mild hyperthermia induced using an extracorporeal Focused Ultrasound (FUS) device. ThermoDox® is a specially formulated long-circulating and thermosensitive liposome, activated by conditions of mild hyperthermia, to release its cytotoxic doxorubicin content. FUS offers non-invasive and non-ionising app...

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Department:
Nuffield Department of Surgical Sciences
Role:
Author, Copyright Holder

Contributors

Department:
Institute of Biomedical Engineering, University of Oxford
Role:
Supervisor
Department:
Department of Radiology, Oxford University Hospitals NHS Foundation Trust
Role:
Supervisor
Department:
Institute of Biomedical Engineering, University of Oxford
Role:
Supervisor
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Grant:
OxBRC2
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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