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Thesis

A microscopic study of cohesin

Abstract:

Cohesin is a ring-shaped Smc (Structural Maintenance of Chromosomes) complex that mediates DNA-DNA interactions between chromosomes (sister chromatid cohesion) and within chromosomes (looping). The mechanisms behind loop formation and cohesion establishment are not known despite cohesin's discovery 20 years ago. In this thesis findings are presented from two projects: one examining the establishment of sister chromatid cohesion and the other the formation of DNA loops by cohesin.

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Role:
Supervisor
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Grant:
294401
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Grant:
091859/Z/10/Z
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Grant:
C573/A12386
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Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
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