Thesis
The lectin pathway of complement activation
- Abstract:
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The complement system is an important immune system mechanism involved in both the recognition and elimination of invading pathogens. It is activated by three different pathways: The classical pathway, which relies on binding of C1, and results in the cleavage of C4 and C2 through activation of C1r and C1s; the alternative pathway that relies on the spontaneous hydrolysis of C3 and the lectin pathway. The lectin pathway is activated by binding of Mannan-binding lectin (MBL) or the ficolins (L...
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- Publication date:
- 2007
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:46255854-bfba-4d57-9185-3e6ed970a2db
- Local pid:
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ora:1765
- Deposit date:
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2008-03-14
Terms of use
- Copyright holder:
- Krarup, A
- Copyright date:
- 2007
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