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Thesis

Haematopoietic stem/progenitor cell interactions with the bone marrow vascular niche

Abstract:

Umbilical cord blood (UCB) is used as a source of haematopoietic stem cells (HSCs) for transplantation but shows defective homing to the bone marrow niche and delayed haematological reconstitution. Following transplantation, HSCs will home to the bone marrow in response to the CXCL12 chemokine, adhere to the bone marrow sinusoidal endothelial cells and then migrate into and lodge in bone marrow niches. In addition to CXCR4, a variety of molecules have been described as being important in thes...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Clinical Laboratory Sciences
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:452da334-bd4e-45c7-a7bd-fc8767d1239c
Local pid:
ora:8261

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