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Thesis

Computational methods for the study of immunoglobulin aggregation

Abstract:

Protein aggregation is a major challenge in the development of antibody-based therapeutics. Therapeutic antibodies are produced and stored in high concentrations and under fluctuating conditions unfavourable for their stability. Aggregation of these proteins in solution leads to serious consequences for patients, with the initiation of immune reactions, which have the potential to be fatal, and in the loss of clinical potency. The types of aggregates formed by antibodies, and the processes...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:43c0950e-7f58-48b9-899d-74dcfee35887
Local pid:
ora:10826

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