Cellular and biochemical characterisation of ERCC6L2

Thesis

Background and aims: ERCC6L2 is a member of the Snf2 ATPase superfamily that has been linked to the DNA damage response (DDR). Past work from our group demonstrated that ERCC6L2KO cells are sensitive to the double-strand break (DSB) inducers etoposide and phleomycin. However, the precise nature of the role that ERCC6L2 plays in the DDR and how it functions to preserve genome stability, remain unclear. Several mutations have been identified in ERCC6L2 which result in a distinct subty...

Expand abstract

Authors: Armstrong, L

• DOI: 10.5287/ora-yqdboayp2
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: DNA damage response; ERCC6L2; double strand break repair; replication stress; inherited bone marrow failure; Snf2 ATPase; genome stability
• Subjects: DNA damage; DNA repair; DNA replication