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Crystallographic studies on 2-oxoglutarate dependent oxygenases

Abstract:

The Fe(II) and 2-oxoglutarate dependent oxygenases (2OG oxygenases) catalyse a broad range of oxidative reactions in various organisms. 2OG oxygenases use 2OG and molecular oxygen to catalyse the oxidation of a variety of substrates including small molecules, fatty acids, nucleic acids and proteins. Several human 2OG oxygenases are implicated in diseases. The fat mass and obesity associated protein (FTO) is linked to obesity, whilst collagen prolyl-4-hydroxylases (CPHs), the procollagen ly...

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Institution:
University of Oxford
Oxford college:
Wolfson College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory

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Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:42a3e0fe-3131-4618-9007-f596da83412b
Local pid:
ora:9062

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