Journal article
Discerning the ancestry of European Americans in genetic association studies
- Abstract:
- European Americans are often treated as a homogeneous group, but in fact form a structured population due to historical immigration of diverse source populations. Discerning the ancestry of European Americans genotyped in association studies is important in order to prevent false-positive or false-negative associations due to population stratification and to identify genetic variants whose contribution to disease risk differs across European ancestries. Here, we investigate empirical patterns of population structure in European Americans, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main source of European American population structure. Building on this insight, we constructed a panel of 300 validated markers that are highly informative for distinguishing these ancestries. We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1371/journal.pgen.0030236
Authors
+ "Burroughs Wellcome Career Development Awards in the Biomedical Sciences", "March of Dimes", "American Diabetes Association Smith Family Foundation Pinnacle Program Project"
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- Funding agency for:
- Hirschhorn, J
+ Burroughs Wellcome Career Development Awards in the Biomedical Sciences
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- Funding agency for:
- Reich, D
- Publisher:
- Public Library of Science
- Journal:
- PLoS Genetics More from this journal
- Volume:
- 4
- Issue:
- 1
- Article number:
- e236
- Publication date:
- 2008-01-18
- Acceptance date:
- 2007-11-16
- DOI:
- EISSN:
-
1553-7404
- ISSN:
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1553-7390
- Language:
-
English
- Keywords:
- UUID:
-
uuid:40cc23aa-e321-4f5d-9b62-9dffe0dd7023
- Local pid:
-
ora:5171
- Deposit date:
-
2011-03-24
- ARK identifier:
Terms of use
- Copyright holder:
- Price et al
- Copyright date:
- 2008
- Notes:
- Copyright: © 2008 Price et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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