Use of viral fusion proteins to develop tumour - antigen presenting cell hybrids leading to cross-presentation of tumour antigens

Thesis

Cancer immunotherapy is a growing area of research with a great deal of potential yet to be explored. The development of therapeutic cancer vaccines is a technically challenging but highly desirable approach within the realm of immunotherapy. One approach, involving formation of tumour and dendritic cell fusions to improve immune presentation of tumour antigens has previously been shown to have a positive effect on tumour regression with no reported cytotoxicity. Building on this, the generat...

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Authors: Mahnoor

• DOI: 10.5287/ora-erpxkevmr
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: antigen cross-presentation; fusion proteins; viral fusion; tumour