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Thesis

Tetramates as antibacterial and anticancer core scaffolds

Abstract:

This thesis is concerned with the synthesis of small molecules that mimic tetramate- and pyrrolidinone-containing natural products, and the evaluation of their antibacterial and anticancer properties.

Chapter 1 exposes the need for new antibiotics due to the emergence of resistance to current drugs, and it discusses the value of the natural product inspired approach for drug discovery. It also gives an overview of the structure, synthesis and biological properties of the natural...

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Laia Josa Cullere More by this author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:

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