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Thesis

Structure-function studies of the bacterial dsDNA translocase FtsK

Abstract:

DNA translocases are molecular motors that use energy from nucleotide triphosphate (NTP) hydrolysis to move along, pump, remodel or clear DNA. Unlike helicases, double-stranded DNA (dsDNA) translocases do not unwind DNA; their action has no net product apart from inducing supercoils as a result of groove-tracking, which has hampered their characterisation. Many dsDNA translocases appear to have biased directionality. However, the inherent symmetry of dsDNA requires that translocase activit...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Prof. David Sherratt
Oxford college:
Magdalen College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
More from this funder
Funding agency for:
Graham, JE
Grant:
077470/Z/05/Z
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:3f4d5ee0-09fa-482b-a90c-62f3acfc788b
Local pid:
ora:11600
Deposit date:
2015-06-08

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