Identification and functional analysis of type 2 innate lymphoid cells in the skin and in lesional skin biopsies of patients with atopic dermatitis

Thesis

Over the past four years, a previously unrecognised family of innate effector cells has been identified. Their comprehensive functional capabilities range from lymphoid organogenesis, tissue remodelling, wound healing, immune protection and homeostasis to contribution to inflammation and allergic responses. Here we investigate the presence and function of type 2 innate lymphoid cells (ILC2) in the skin. We show that human ILC2 are resident in human skin and express RORA and GATA3, and skin...

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Authors: Salimi, M

• Alternative title: The role of type 2 innate lymphoid cells in pathogenesis of atopic dermatitis
• Publication date: 2014
• DOI: 10.5287/ora-mzxd48kx8
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Skin; Atopic dermatitis; Innate lymphoid cells
• Subjects: Immunology