Exploring the relationship between cancer metabolism and oncolytic adenoviruses

Thesis

Tumour cells exhibiting the Warburg effect rely mostly upon aerobic glycolysis for ATP production and have a notable addiction to anaplerotic use of glutamine for macromolecular synthesis. This strategy maximises cellular biosynthetic potential and provides an attractive anabolic environment for viral infection. Here, we evaluate infection of highly permissive cells (A549 cells) and poorly permissive cells (SKOV3) with wildtype adenoviruses, and the oncolytic chimeric adenovirus enadenotu...

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Authors: Dyer, A

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: oncolytic virotherapy; cancer immunotherapy; tumour metabolism; virology; gene therapy; metabolism; oncolytic; oncology
• Subjects: Virology; oncolytic virotherapy; Metabolism; tumour metabolism; Cancer--Immunotherapy; oncolytic; Oncology; oncology; Gene therapy