Computed tomography phenotyping of perivascular adipose tissue for cardiovascular disease diagnosis and risk stratification

Thesis

Coronary inflammation is a major driver of cardiovascular disease and has been implicated in all stages of coronary atherosclerosis, from the early formation of coronary lesions to plaque rupture. Far from being an innocent bystander, perivascular adipose tissue (PVAT) is now recognised as a critical regulator of vascular biology. Further to its direct effects on the arterial wall through outside-to-inside paracrine signals mediated by a wide range of adipocytokines, recent evidence sugge...

Expand abstract

Authors: Oikonomou, EK

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: inflammation; perivascular fat; cardiovascular imaging; pericoronary fat; radiomics; computed tomography; adipose tissue
• Subjects: Cardiovascular disease; Coronary arteries; Coronary heart disease; Imaging; Medical sciences