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Thesis

Dynamic nuclear polarisation as a probe of metabolism in pathophysiology

Abstract:

Spin-half nuclei in a magnetic field possessing a population difference in excess of that expected at thermal equilibrium are said to be hyperpolarised. Dynamic Nuclear Polarisation (DNP) is a method to generate hyperpolarised systems, pumping nuclear spins into a given state at low temperature. Hyperpolarised samples can be rapidly dissolved in a hot solvent, and maintain a highly polarised spin population that relaxes to the new thermal equilibrium over several minutes. It is possible to...

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Department:
Physics
Department:
Physics; DPAG; Oncology; CV Medicine
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Department:
Oncology
Role:
Supervisor
Department:
Physics
Role:
Supervisor
Department:
Physics
Role:
Supervisor
Department:
University College London
Role:
Examiner
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Grant:
FS/10/002/28078, FS/14/17/30634, FS/11/50/29038, & RG/11/9/28921
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Grant:
Damian Tyler/J Miller
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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