Application of metabolomics in inflammatory demyelinating diseases of the central nervous system

Thesis

The prototypical central nervous system (CNS) inflammatory demyelinating disease (IDD) is multiple sclerosis (MS), which is a complex, immune-mediated disease involving genetic and environmental factors, both contributing and interacting, to produce the underlying immunopathogenesis. The inherent pathogenic heterogeneity within MS makes it challenging for a single candidate biofluid marker to reflect all the underlying disease processes, both neuroinflammatory and neurodegenerative, at t...

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Authors: Yeo, T

• DOI: 10.5287/ora-zbpvmk8pk
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: animal model; relapse; relapsing-remitting; cerebrospinal fluid; multiple sclerosis; secondary progressive; serum; metabolites; neuromyelitis optica spectrum disroder; delayed-type hypersensitivity; metabolomics; inflammatory demyelination
• Subjects: Metabolomics; Neurology