Integrated characterisation of carotid atherosclerosis - from magnetic resonance imaging to plaque macrophage profiling

Thesis

Cardiovascular morbidity and mortality remain the most serious global public health challenge. With the evolution in global socio-economic activities and the associated lifestyle changes, there is an impending epidemic of obesity, insulin resistance, metabolic syndrome, and diabetes mellitus, all of which fuel premature coronary artery disease and stroke. In the post-statin era, despite considerable efforts in anti-atherosclerotic drug development, a significant number of these potential c...

Expand abstract

Authors: Chai, J

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: microarray; lipid; carotid; cholesterol efflux; atherosclerosis; nicotinic acid; MRI; macrophage; laser capture microdissection; GPR109A; transcriptomic; T2 mapping
• Subjects: Cardiovascular system--Diseases