Substrate analogue studies on cephalosporin biosynthesis enzymes

Thesis

The application of β-lactams as chemotherapeutic agents in the 1940s fundamentally changed the course of medicine. Some 80 years later, β-lactam antibiotics still have a central role in modern medicine. The biosynthesis of β-lactams is arguably as remarkable as their applications. The research described in this thesis focussed on the first two steps in the biosynthesis of cephalosporins from penicillin N; the ring-expansion of penicillin N to deacetoxycephalosporin C (DAOC) and the subsequ...

Expand abstract

Authors: Foster, F

• DOI: 10.5287/ora-brgvjo8zx
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Beta-lactams; Substrate analogoues; Cephalosporins; Antibiotics
• Subjects: Chemistry, Organic; Biochemistry; Enzymology