Thesis
Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
- Abstract:
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The Hedgehog signalling pathway is an essential developmental pathway present in all bilaterians that is involved in embryogenesis, body patterning and stem cell homeostasis. Dysregulation of the Hh pathway leads to various kinds of cancer, such as basal cell carcinoma and medulloblastoma. Smoothened (SMO), a Frizzled-type G-protein coupled receptor (GPCR), is the essential transmembrane signal transducer within the Hh pathway, conveying the signal from the upstream transmembrane protein, ...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:38abef20-ae98-4835-919c-73afc21a6252
- Deposit date:
- 2018-04-12
Related Items
Terms of use
- Copyright holder:
- Byrne, E
- Copyright date:
- 2017
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