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Thesis

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened

Abstract:

The Hedgehog signalling pathway is an essential developmental pathway present in all bilaterians that is involved in embryogenesis, body patterning and stem cell homeostasis. Dysregulation of the Hh pathway leads to various kinds of cancer, such as basal cell carcinoma and medulloblastoma. Smoothened (SMO), a Frizzled-type G-protein coupled receptor (GPCR), is the essential transmembrane signal transducer within the Hh pathway, conveying the signal from the upstream transmembrane protein, ...

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Department:
Structural Biology

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Department:
Structural Biology
Role:
Supervisor
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Funding agency for:
Eamon Byrne
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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