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Thesis

The characterization and engineering of human antigen-specific cytotoxic T cells

Abstract:

This D.Phil. thesis focuses on human antigen-specific cytotoxic T lymphocytes (CTLs). In the first part of the thesis, the impact of antigen stimulation strength on CTL activation was investigated by evaluating the global transcriptomes of a wellcharacterized CTL clone and some of its surface protein expressions, with particular focus on immune checkpoint receptors. Based on the gene differentiations, an 'EGR2-CCL1-4-1BB' pathway, which is sensitive to very low-strength antigen stimu...

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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