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Olefin metathesis for site-selective protein modification

Abstract:

Site-selective protein modification has become an important tool to study protein functions in chemical biology. In the preliminary work, allyl sulfides were found to be reactive substrates in aqueous cross-metathesis (CM) enabling the first examples of protein modification via this approach. In order to access the enhanced CM reactivity of allyl sulfide on proteins, facile chemical methods to install S-allyl cysteine on protein surface were developed. In particular, a cysteine-specific al...

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Institution:
University of Oxford
Oxford college:
St Hilda's College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemical Biology

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:37d998f6-c1cd-4e2c-9f9f-89d197d21016
Local pid:
ora:7134

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