Journal article icon

Journal article

Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.

Abstract:

PURPOSE: Fluourouracil (FU) is a mainstay of chemotherapy, although toxicities are common. Genetic biomarkers have been used to predict these adverse events, but their utility is uncertain. PATIENTS AND METHODS: We tested candidate polymorphisms identified from a systematic literature search for associations with capecitabine toxicity in 927 patients with colorectal cancer in the Quick and Simple and Reliable trial (QUASAR2). We then performed meta-analysis of QUASAR2 and 16 published studies...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1200/jco.2013.51.1857

Authors


Rosmarin, D More by this author
Domingo, E More by this author
Expand authors...
Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume:
32
Issue:
10
Pages:
1031-1039
Publication date:
2014-04-05
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:37149915-98cb-4193-bf44-38c61bf80608
Source identifiers:
451099
Local pid:
pubs:451099

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP