- Abstract:
-
PURPOSE: Fluourouracil (FU) is a mainstay of chemotherapy, although toxicities are common. Genetic biomarkers have been used to predict these adverse events, but their utility is uncertain. PATIENTS AND METHODS: We tested candidate polymorphisms identified from a systematic literature search for associations with capecitabine toxicity in 927 patients with colorectal cancer in the Quick and Simple and Reliable trial (QUASAR2). We then performed meta-analysis of QUASAR2 and 16 published studies...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1200/jco.2013.51.1857
-
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- Journal:
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Volume:
- 32
- Issue:
- 10
- Pages:
- 1031-1039
- Publication date:
- 2014-04-05
- DOI:
- EISSN:
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1527-7755
- ISSN:
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0732-183X
- URN:
-
uuid:37149915-98cb-4193-bf44-38c61bf80608
- Source identifiers:
-
451099
- Local pid:
- pubs:451099
- Copyright date:
- 2014
Journal article
Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
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