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Thesis

Investigating break induced replication and template switching in fission yeast

Abstract:

Single-stranded DNA breaks (SSBs) are the most common DNA lesion a cell can suffer with ~1 SSB formed every 5 seconds in a mammalian cell under normal conditions. Hence, a significant number of SSBs are encountered by replication forks in S-phase and these encounters can result in double-stranded DNA breaks (DSBs), which are highly toxic lesions. Determining how DSBs are formed from such encounters and how these are repaired has been an important area of research for many years. Until rece...

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Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0003-0951-3374
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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