Thesis
Structural studies of membrane proteins in organellar & cellular homeostasis
- Abstract:
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Cells rely on organelle-specific membrane proteins and lipids to maintain ionic and pH homeostasis and to oversee the biogenesis/quality control of multi-pass proteins. This thesis examines two such systems: the lysosomal chloride/proton antiporter CLC7 and a putative endoplasmic reticulum (ER) chaperone, RUSF1.
Expand abstract
In the first half of the thesis, through cryo-electron microscopy, I solved three structures of human CLC7: wild-type transporter complex bound to a lysosomal signalling lipid ...
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- Files:
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(Preview, Dissemination version, pdf, 82.7MB, Terms of use)
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Authors
Contributors
+ Newstead, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Biochemistry
- Role:
- Supervisor
- ORCID:
- 0000-0001-7432-2270
+ Higgins, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Biochemistry
- Role:
- Supervisor
- ORCID:
- 0000-0002-2870-1955
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Deposit date:
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2026-04-11
- ARK identifier:
Terms of use
- Copyright holder:
- Yifei (Abby) Lin
- Copyright date:
- 2025
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