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Thesis

Mechanistic studies on human prolyl hydroxylase domain 2

Abstract:

2-Oxoglutarate (2OG) and Fe(II) dependent oxygenases, in particular human PHD1-3, catalyse the trans-4-prolyl hydroxylation of hypoxia inducible transcriptional factors (HIFs). HIFs are α,β-heterodimeric proteins that mediate cellular responses to hypoxia in animals. At sufficiently high concentrations of O2, the PHDs catalyse hydroxylation of HIFα at two proline residues located in the C-terminal and N-terminal oxygen degradation domains (CODD and NODD). HIFα prolyl hydr...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Oxford college:
Lincoln College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
ORCID:
0000-0002-0290-6565

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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